향균 능력을 갖는 Ag 인산염 글라스가 적용된 치과용 복합레진의 평가
Evaluation of Dental Composite Dispersed with Silver-Doped Phosphate Antibacterial Glasses
문호진, Ahmed El-Fiqi, 차재령, 이성훈, 공명선, 김해원, 백동헌, 신동훈,
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문호진 ( Moon Ho-Jin ) - 단국대학교 치과대학 치과보존학교실
( Ahmed El-Fiqi ) - 단국대학교 조직재생공학연구소
차재령 ( Cha Jae-Ryung ) - 단국대학교 나노바이오의과학과
이성훈 ( Lee Sung-Hoon ) - 단국대학교 치과대학 구강미생물학교실
공명선 ( Gong Myoung-Seun ) - 단국대학교 나노바이오의과학과
김해원 ( Kim Hae-Won ) - 단국대학교 조직재생공학연구소
백동헌 ( Baek Dong-Heon ) - 단국대학교 치과대학 구강미생물학교실
신동훈 ( Shin Dong-Hoon ) - 단국대학교 치과대학 치과보존학교실
KMID : 0362220120390040311
Abstract
The purpose of this study was to investigate the effect of adding antibacterial silver-doped phosphate glasses on the antibacterial properties of conventional dental composite. Silver-doped phosphate antibacterial glasses were prepared by the melting method. The antibacterial effects of some undoped and silver-doped glasses of composition , (where x=0, 1, 1.5, 2 mol %), against Staphylococcus aureus, Escherichia coli and Streptococcus mutans micro-organism using agar diffusion test and mininum inhibitory concentration test were investigated. A visible light system of camphorquinone photo-initiator and 2-(dimethylamino)ethyl methacrylate photo-accelerator was utilized to activate the resin matrix in the polymer composites. The degree of conversion, depth of cure, mechanical strength and antibacterial properties of dental composites with glass powder and resin matrix were investigated. Silver-doped glasses showed an increase in inhibition zone diameter against the tested micro-organisms. Composite groups that contain small amounts of phosphate glasses (Group 0~3) demonstrated no significant difference in compressive and flexural strength, but composite that has maximum filler use with phosphate glass (Group 4) showed severe decrease in both mechanical strength. There was no signigicant difference in degree of conversion. However, there was significant decrease in depth of cure for the Group 4. Silver-doped phosphate antibacterial glasses inhibited the growth of the major oral pathogen S. mutans. But there was no significant difference in antibacterial effects when they mixed into dental composite. These results indicate that a dental resin composite with 2 % Ag-doped phosphate glass may not be useful clinically because its insufficient anticariogenic effect, even though it showed favorable mechanical strength and polymeric behavior. Further study should be needed to overcome the low antibacterial effect and to establish the effective mechanism and dynamic model for the anticariogenic composite resin.
키워드
Anticariogenic; Composite resin; Silver-doped phospate glass; Streptococcus mutans
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